Table 6.

Univariate & multivariate cox proportional hazards model to predict factors associated with RFS in high-risk GISTs with operation only

Variable	Univariate		Multivariate
	Hazard Ratio (95% Cl)	P value	Hazard Ratio (95% Cl)	P value
Total
Age	1.120 (0.524-2.393)	0.770	0.800 (0.357-1.794)	0.588
Gender	0.584 (0.315-1.081)	0.087	0.582 (0.310-1.093)	0.092
Tumor site	1.062 (0.770-1.466)	0.714	1.163 (0.845-1.600)	0.354
Tumor size	1.582 (1.001-2.500)	0.049*	1.726 (1.061-2.808)	0.028*
Mitosis count	2.060 (1.480-2.868)	< 0.001**	2.159 (1.518-3.072)	< 0.001**
EGFR	0.567 (0.327-0.984)	0.044*	0.608 (0.319-1.159)	0.131
HER2	0.804 (0.464-1.394)	0.438	0.958 (0.505-1.817)	0.895
HER4	1.301 (0.742-2.284)	0.359	1.967 (1.028-3.761)	0.041*
Stomach sub-group
Age	1.173 (0.265-5.183)	0.833	0.579 (0.106-3.150)	0.527
Gender	0.694 (0.224-2.154)	0.528	0.725 (0.204-2.572)	0.618
Tumor size	1.060 (0.557-2.019)	0.859	1.450 (0.608-3.458)	0.402
Mitosis count	3.590 (1.626-7.928)	0.002**	4.641 (1.690-12.740)	0.003**
EGFR	0.533 (0.197-1.440)	0.215	0.563 (0.145-2.192)	0.408
HER2	0.856 (0.320-2.285)	0.756	1.268 (0.386-4.166)	0.696
HER4	3.345 (1.076-10.394)	0.037*	4.632 (1.269-16.904)	0.020*
Small bowel sub-group
Age	1.039 (0.357-3.025)	0.944	0.804 (0.237-2.731)	0.727
Gender	0.495 (0.215-1.136)	0.097	0.513 (0.217-1.212)	0.128
Tumor size	1.933 (0.978-3.821)	0.058	1.678 (0.799-3.524)	0.172
Mitosis count	2.061 (1.296-3.279)	0.002**	1.984 (1.199-3.285)	0.008**
EGFR	0.452 (0.210-0.974)	0.043*	0.551 (0.232-1.306)	0.176
HER2	0.689 (0.321-1.476)	0.337	0.959 (0.366-2.515)	0.933
HER4	0.742 (0.346-1.589)	0.442	1.048 (0.400-2.742)	0.924

^*P < 0.05;

^**P < 0.01.