Table 7.
Univariate & multivariate cox proportional hazards model to predict factors associated with RFS in high-risk GISTs with imatinib adjuvant therapy
| Variable | Univariate | Multivariate | ||
|---|---|---|---|---|
|
|
|
|||
| Hazard Ratio (95% Cl) | P value | Hazard Ratio (95% Cl) | P value | |
| Age | 0.684 (0.188-2.498) | 0.566 | 0.582 (0.131-2.594) | 0.478 |
| Gender | 0.993 (0.332-2.974) | 0.990 | 0.828 (0.223-3.071) | 0.777 |
| Tumor site | 1.340 (0.701-2.561) | 0.375 | 2.230 (1.065-4.669) | 0.033* |
| Tumor size | 1.811 (0.704-4.659) | 0.218 | 1.778 (0.499-6.330) | 0.374 |
| Mitosis count | 1.514 (0.749-3.059) | 0.248 | 2.243 (0.942-5.345) | 0.068 |
| EGFR | 0.260 (0.070-0.957) | 0.043* | 0.195 (0.046-0.827) | 0.027* |
| HER2 | 0.578 (0.192-1.735) | 0.328 | 0.871 (0.244-3.113) | 0.832 |
| HER4 | 0.891 (0.294-2.706) | 0.839 | 1.216 (0.353-4.193) | 0.756 |
*
P < 0.05.