Table 3.
Correlation between the serum level of Hsp90-beta and clinicopathologic factors of lung cancer patients
| Groups | N | Level of Hsp90-beta | ||||
|---|---|---|---|---|---|---|
|
| ||||||
| M±SD (pg/ml) | df | F | P | |||
| Resource | ||||||
| Normal | 256 | 0.95±0.19 | 2 | 81.79 | < 0.0005 | |
| Benign | 221 | 1.04±0.21 | ||||
| Cancerous | 268 | 1.34±0.09■ | ||||
| Histology | ||||||
| LAC | 83 | 1.34±0.089 | 2 | 57.65 | < 0.0005 | |
| LSCC | 146 | 1.32±0.092 | ||||
| SCLC | 39 | 1.39±0.069★ | ||||
| Pathologic grade | ||||||
| Undifferentiated | 32 | 1.39±0.069★★ | 3 | 113.13 | < 0.0005 | |
| Poorly | 99 | 1.39±0.055★★ | ||||
| Moderate | 84 | 1.32±0.063 | ||||
| Well | 53 | 1.23±0.084 | ||||
| Lymphatic invasion | ||||||
| N0 | 69 | 1.26±0.10 | 3 | 63.19 | < 0.0005 | |
| N1-N2 | 103 | 1.35±0.058★★★ | ||||
| N3 | 60 | 1.39±0.066★★★ | ||||
| Unavailable | 36 | 1.33±0.23 | ||||
| TNM stage | ||||||
| I-II | 71 | 1.24±0.09 | 2 | |||
| III-IV | 165 | 1.36±0.06▲ | 102.49 | < 0.0005 | ||
| Unavailable | 32 | 1.30±0.11 | ||||
| Pleural invasion | ||||||
| absent | 72 | 1.34±0.089 | 2 | 72.67 | < 0.0005 | |
| Present | 196 | 1.33±0.23 | ||||
LAC, adenocarcinoma of the lung; LSCC, squamous cell carcinoma of the lung; SCLC, small cell lung cancer; LCLC, large cell lung cancer;
■
cancerous group compared with benign and normal group;
★
SCLC compared with LAC and LSCC;
★★
undifferentiated and poorly compared with moderate and well;
★★★
N1-N3 compared with N0;
▲
III-IV compared with I-II;
M±SD, mean±standard deviation; df, degree of freedom.