Table 2.

Levels of staining of prostaglandin receptors EP1-4 are different in NU, NMIBC and MIBC determined using the Mann-Whitney U test

	EP1 (c)	EP1 (n)	EP2 (c)	EP2 (n)	EP3 (c)	EP3 (n)	EP4 (c)
NU vs BCA	<0.001*↓	<0.001 *↓	<0.001 *↓	<0.001 *↓	0.001 *↓	<0.001 *↓	0.914
NU vs NMIBC	0.003 *↓	<0.001 *↓	<0.001 *↓	<0.001 *↓	0.009 *↓	<0.001 *↓	0.117
NU vs MIBC	<0.001 *↓	<0.001 *↓	<0.001 *↓	<0.001 *↓	<0.001 *↓	<0.001 *↓	0.037 *↑
NMIBC vs MIBC	<0.001*↑	0.071	0.120	0.004 *↓	0.010 *↑	0.015 *↓	<0.001 *↑

^*↑indicates positive correlation;

^*↓indicates negative correlation.

Abbreviations: NU=normal urothelium; BCA=bladder cancer; NMIBC=non-muscle invasive bladder cancer; MIBC=muscle invasive bladder cancer; (c)=cytoplasmic; (n)=nuclear; significant values are shown in bold.