Table 3.

Differences between EP1-4 expression for different pathological stages and grades in patients with NMIBC and MIBC

	EP1 (c)	EP1 (n)	EP2 (c)	EP2 (n)	EP3 (c)	EP3 (n)	EP4 (c)
NMIBC
pTa vs pT1	0.001*↑	0.004 *↑	0.001 *↑	<0.001 *↑	0.237	0.192	0.102
pTa vs pTis	<0.001 *↑	0.182	0.038*↓	0.516	0.614	0.751	0.053
pTis vs pTa	0.266	0.368	<0.001 *↑	0.001 *↑	0.690	0.262	0.245
G1 vs G2	0.002 *↑	0.685	0.238	0.745	0.078	0.252	0.010 *↑
G1 vs G3	<0.001 *↑	0.067	0.055	0.354	0.388	0.894	0.004 *↑
G2 vs G3	0.040 *↑	0.147	0.006*↓	0.459	0.670	0.387	0.400
MIBC
pT2 vs pT3	0.156	<0.001 *↓	0.980	<0.001 *↓	0.062	<0.001 *↓	0.025 *↑
pT2 vs pT4	0.348	0.029 *↓	0.947	<0.001 *↓	0.689	0.001 *↓	0.855
pT3 vs pT4	0.791	0.054	0.972	0.128	0.027 *↑	0.640	0.031 *↓
pN0 vs pN+	0.001 *↑	0.433	0.089	0.103	0.601	0.115	0.005 *↑
cM0 vs cM+	0.058	0.673	0.126	0.904	0.271	0.561	0.140
G2 vs G3	0.351	0.674	0.891	0.611	0.496	0.819	0.019 *↑

^*↑indicates positive correlation;

^*↓indicates negative correlation.

Abbreviations: NMIBC=non-muscle invasive bladder cancer; MIBC=muscle invasive bladder cancer; (c)=cytoplasmic; (n)=nuclear; significant values are shown in bold.