Table 5.

Cox proportional hazard analysis of EP1-4 and pathological features in correlation to cancer-specific survival (CSS) and bladder-cancer recurrence in patients with MIBC

	Recurrence-free survival univariate analysis			CSS univariate analysis			CSS multivariate analysis
	p	SE	HR (95% CI)	p	SE	HR (95% CI)	p	SE	HR (95% CI)
EP1 (c)	0.325	0.053	1.054 (0.950-1.169)	0.027	0.060	1.142 (1.015-1.286)	0.167	0.101	1.150 (0.943-1.403)
EP1 (n)	0.154	0.040	1.059 (0.979-1.147)	0.110	0.052	1.087 (0.981-1.203)
EP2 (c)	0.171	0.060	0.922 (0.820-1.036)	0.331	0.076	0.929 (0.800-1.078)
EP2 (n)	0.390	0.081	0.933 (0.796-1.093)	0.404	0.106	0.915 (0.743-1.127)
EP3 (c)	0.660	0.046	0.980 (0.895-1.073)	0.945	0.060	0.996 (0.885-1.120)
EP3 (n)	0.950	0.067	0.996 (0.872-1.137)	0.595	0.086	1.047 (0.884-1.240)
EP4 (c)	0.868	0.047	0.992 (0.904-1.086)	0.475	0.061	1.044 (0.927-1.176)
pTstage	0.076	0.050	1.092 (0.991-1.205)	0.022	0.065	1.160 (1.022-1.318)	0.017	0.091	1.242 (1.040-1.483)
Grade	0.539	0.226	0.870 (0.559-1.355)	0.068	0.338	1.853 (0.955-3.598)
pNstage	0.396	0.131	1.118 (0.864-1.447)	0.049	0.153	1.351 (1.002-1.823)	0.896	0.212	1.028 (0.679-1.557)
cMstage	0.236	1.022	3.355 (0.453-24.858)	0.000	0.561	9.879 (3.250-29.972)	0.001	0.697	9.421 (2.406-36.899)

Abbreviations: CSS=cancer-specific survival; (c)=cytoplasmic; (n)=nuclear; P=p-value; SE=standard error; HR=hazard ratio; significant values are shown in bold.