Fig. 5.

The pharmacophore model was developed using the X-ray L. infantum tyrosine aminotransferase structure. Amino acceptor group of KMTB is directed towards amine group of PMP transit state (surrounded by red circle). Carbons, oxygens, nitrogens, sulfurs and phosphates are shown by gray, red, blue, yellow and orange respectively. Each sphere indicates the location tolerance of a particular feature point. Hydrogen bonds, hydrophobic and electrostatic interactions are shown by green, dark blue and cyan respectively. (For interpretation of the references to colours in this figure legend, the reader is referred to the web version of this paper.)