Table 1.
Distribution of drug classes across 69 hit anti-Wolbachia compounds. 121 compounds inhibited intracellular Wolbachia bacteria by 0.5 logs or more. Out of these, 69 belong to diverse classes of approved drugs and are available in an oral formulation and hence constitute hits for further analysis.
| Drug class | Number of hits | Percent of hits (%) |
|---|---|---|
| Anti-infectives | 24 | 35 |
| Anti-psychotics/anti-convulsants | 8 | 12 |
| Natural products/nutraceuticals | 7 | 10 |
| Receptor antagonists | 6 | 9 |
| Anti-hypertensives | 6 | 9 |
| Muscle relaxants | 5 | 7 |
| Others | 5 | 7 |
| Non-steroidal anti-inflammatories | 4 | 6 |
| Anti-neoplastic agents | 4 | 6 |