Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
A schematic representation of hormonal control of pubertal development. Kisspeptin from Kiss neurons stimulates GnRH secretion by a direct effect on GnRH neurons. KiSS-1 neurons in the ARC appear to be involved in the negative feedback regulation of GnRH/LH by sex steroids. The expression of KiSS-1 mRNA in the arcuate is inhibited by estradiol (E), and testosterone (T). + = stimulation, – = inhibition
