TABLE 3.

Meta-analyzed associations between SNPs and macronutrient intake¹

						PUFA, % of total energy		MUFA, % of total energy		SFA, % of total energy		Total fat, % of total energy		Total carbohydrate, % of total energy		Total protein, % of total energy
SNP	Alleles, minor/major	Position	Location	Minor allele frequency	N2	β ± SE	P	β ± SE	P	β ± SE	P	β ± SE	P	β ± SE	P	β ± SE	P
rs504836	C/T	55980062	Intronic3	0.26	7417	−0.002 ± 0.03	0.96	0.01 ± 0.06	0.92*	0.01 ± 0.05	0.93	0.06 ± 0.13	0.63	0.17 ± 0.15	0.25*	0.13 ± 0.06	0.04*
rs6858749	T/C	55985194	Intronic3	0.41	8316	0.02 ± 0.02	0.43	0.02 ± 0.04	0.63	0.003 ± 0.04	0.95	0.09 ± 0.095	0.33	0.05 ± 0.11	0.62*	0.06 ± 0.05	0.18*
rs1047354	G/A	55990340	Intergenic	0.34	14,274	−0.03 ± 0.02	0.15	−0.003 ± 0.03	0.92	0.01 ± 0.04	0.84	−0.03 ± 0.08	0.71	0.08 ± 0.09	0.38	0.12 ± 0.03	0.0002*,4
rs10462028	G/A	55993057	Downstream	0.34	14,305	−0.02 ± 0.02	0.25*,5	−0.07 ± 0.03	0.05	−0.02 ± 0.04	0.64	−0.12 ± 0.08	0.13	0.09 ± 0.09	0.34	0.02 ± 0.04	0.69
rs1801260	C/T	55996126	3′UTR	0.31	8316	0.02 ± 0.02	0.34	0.04 ± 0.04	0.33	0.03 ± 0.04	0.54	0.10 ± 0.11	0.33	−0.09 ± 0.11	0.41	0.09 ± 0.05	0.85
rs3792603	G/A	55996815	Intronic	0.18	8313	0.002 ± 0.03	0.93	−0.02 ± 0.06	0.78	0.01 ± 0.06	0.86	0.02 ± 0.12	0.88	−0.10 ± 0.14	0.47	−0.10 ± 0.06	0.09
rs11932595	C/T	56018354	Intronic	0.36	7007	0.01 ± 0.02	0.79*	0.003 ± 0.05	0.95	−0.01 ± 0.05	0.90	0.08 ± 0.11	0.50	−0.17 ± 0.14	0.22	−0.04 ± 0.05	0.51
rs12649507	A/G	56075241	Intronic	0.17	7748	−0.03 ± 0.02	0.16	−0.02 ± 0.05	0.66	0.02 ± 0.05	0.71	−0.03 ± 0.11	0.80	−0.04 ± 0.12	0.74	−0.03 ± 0.05	0.62*
rs11726609	A/T	56095626	Intronic	0.38	14,215	−0.001 ± 0.02	0.97*	−0.06 ± 0.03	0.09	−0.03 ± 0.04	0.49	−0.11 ± 0.08	0.19	0.06 ± 0.09	0.54	0.03 ± 0.04	0.47

¹Additive allele model was adjusted for age, sex, BMI, study site (in the CHS, InCHIANTI, and MESA) and family or population structure (in the Corogene Controls, FOS, and MESA). Association coefficients are shown as βs ± SEs. β represents the change in macronutrient intake (percentage of total energy) per each additional minor allele. Prespecified Bonferroni-corrected significance level of P < 0.002. Heterogeneity statistics (I²) are presented in Supplemental Table 8. *I² > 30%. CHS, Cardiovascular Health Study; FOS, Framingham Offspring Study; HBCS, Helsinki Birth Cohort study; InCHIANTI, Invecchiare in Chianti (Aging in the Chianti Area); MESA, Multi-Ethnic Study of Atherosclerosis; SNP, single nucleotide polymorphism; 3′UTR, 3′-untranslated region.

²Number of independent observations in each association analysis. Exact numbers of observations varied for each outcome and are presented in Supplemental Table 8.

³Transmembrane protein 165, TMEM165.

⁴Sensitivity analysis (removal of the HBCS); β ± SE = 0.03 ± 0.03%, P = 0.46, I² =52%.

⁵Sensitivity analysis (removal of the InCHIANTI); β ± SE = −0.05 ± 0.02%, P = 0.03, I² =23%.