TABLE 4.

Meta-analyzed interactions between sleep duration and SNPs on macronutrient intake¹

			PUFA, % of total energy		MUFA, % of total energy		SFA, % of total energy		Total fat, % of total energy		Total carbohydrate, % of total energy		Total protein, % of total energy
SNP	Alleles, minor/major	N2	β ± SE	P	β ± SE	P	β ± SE	P	β ± SE	P	β ± SE	P	β ± SE	P
rs504836	C/T	7417	−0.02 ± 0.02	0.35	−0.07 ± 0.05	0.14	0.03 ± 0.05	0.58	−0.80 ± 0.11	0.47	0.12 ± 0.12	0.32	−0.04 ± 0.05	0.44
rs6858749	T/C	8316	−0.03 ± 0.02	0.12	−0.06 ± 0.08	0.08	0.02 ± 0.03	0.50	−0.09 ± 0.08	0.27	0.08 ± 0.09	0.37	−0.08 ± 0.04	0.04
rs1047354	G/A	14,274	0.03 ± 0.01	0.06	0.02 ± 0.03	0.55	−0.04 ± 0.03	0.24	0.04 ± 0.07	0.63	−0.11 ± 0.08	0.17	0.02 ± 0.03	0.59
rs10462028	G/A	14,305	0.01 ± 0.02	0.41	0.02 ± 0.03	0.54	−0.03 ± 0.04	0.41	0.03 ± 0.08	0.75	0.04 ± 0.09	0.69	−0.04 ± 0.04	0.21
rs1801260	C/T	8316	−0.01 ± 0.02	0.52	−0.04 ± 0.04	0.37	0.02 ± 0.04	0.60	−0.05 ± 0.10	0.64	0.05 ± 0.10	0.65	−0.03 ± 0.05	0.46
rs3792603	G/A	8313	−0.002 ± 0.02	0.89	0.04 ± 0.05	0.45	0.03 ± 0.05	0.60	0.09 ± 0.10	0.37	−0.14 ± 0.11	0.22	−0.05 ± 0.05	0.32
rs11932595	C/T	7007	−0.0002 ± 0.02	0.99	−0.02 ± 0.04	0.72	−0.002 ± 0.04	0.96*	−0.02 ± 0.09	0.86*	0.06 ± 0.11	0.61	−0.04 ± 0.04	0.35
rs12649507	A/G	7748	0.05 ± 0.02	0.01	0.07 ± 0.04	0.07	−0.03 ± 0.04	0.40	0.14 ± 0.09	0.12	−0.07 ± 0.09	0.45	−0.01 ± 0.04	0.88*
rs11726609	A/T	14,215	−0.03 ± 0.02	0.05*	−0.02 ± 0.03	0.53	0.02 ± 0.03	0.54*	−0.05 ± 0.08	0.53	0.11 ± 0.08	0.19	−0.03 ± 0.03	0.45

¹Additive allele model was adjusted for age, sex, BMI, study site (in the CHS, InCHIANTI, and MESA) and family or population structure (in the Corogene Controls, FOS, and MESA). Interaction coefficients are shown as βs ± SEs. β represents the direction and magnitude of the change in macronutrient intake (percentage of total energy) with each additional hour of sleep per each additional minor allele. Prespecified Bonferroni-corrected significance level of P < 0.002. Heterogeneity statistics (I²) are presented in Supplemental Table 9. *I² > 30%. CHS, Cardiovascular Health Study; FOS, Framingham Offspring Study; InCHIANTI, Invecchiare in Chianti (Aging in the Chianti Area); MESA, Multi-Ethnic Study of Atherosclerosis; SNP, single nucleotide polymorphism.

²Number of independent observations in each interaction analysis. Exact numbers of observations varied for each outcome and are presented in Supplemental Table 9.