TABLE 4.

Multivitamin supplement use and major cardiovascular disease events by subgroups of individuals¹

	No. of events
	No use	Multivitamin use	Multivitamin use compared with no use2	P-interaction
Age
<70 y	826	513	1.03 (0.90, 1.19)3
≥70 y	98	57	0.72 (0.48, 1.08)	0.04
BMI
<25 kg/m2	387	272	1.10 (0.91, 1.34)
≥25 kg/m2	536	282	0.96 (0.81, 1.14)	0.45
Smoking status
Nonsmokers	383	250	0.97 (0.80, 1.17)
Past smokers	285	200	1.11 (0.89, 1.39)
Current smokers	255	120	0.98 (0.75, 1.29)	0.56
History of diabetes
No	819	515	0.99 (0.87, 1.14)
Yes	104	55	1.13 (0.76, 1.69)	0.96
History of hypertension
No	494	287	0.91 (0.76, 1.08)
Yes	429	283	1.14 (0.95, 1.38)	0.11
History of hypercholesterolemia
No	536	345	1.03 (0.87, 1.22)
Yes	387	225	0.98 (0.80, 1.20)	0.19
Fruit and vegetables
<3 servings/d	291	143	0.77 (0.55, 1.09)
3 to <7 servings/d	386	227	0.99 (0.83, 1.17)
≥7 servings/d	246	200	1.20 (0.95, 1.51)	0.01
Aspirin arm
No	471	296	1.06 (0.89, 1.27)
Yes	452	274	0.95 (0.79, 1.15)	0.74
β-Carotene arm
No	480	269	0.93 (0.77, 1.11)
Yes	443	301	1.09 (0.91, 1.30)	0.24
Vitamin E arm
No	466	273	0.98 (0.82, 1.18)
Yes	457	297	1.02 (0.86, 1.22)	0.31

¹All statistical tests were conducted by using Cox proportional hazards regression models. Interaction test were done by using the Wald's statistics.

²Multivariable models were adjusted for age, BMI, smoking, physical activity, postmenopausal status, randomized treatment assignment, number of supplements used, family history of myocardial infarction, diabetes history, hypertension history, hypercholesterolemia history, alcohol consumption, and intakes of fruit and vegetables, dietary fiber, SFAs, and PUFAs.

³HR; 95% CI in parentheses (all such values).