TABLE 2.
Genotype frequencies, % |
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Study | n | Minor homozygote (AA) | Heterozygote (AG) | Major homozygote (GG) | MAF | Hardy-Weinberg equilibrium P | HapMap |
BWHHS | 3719 | 0.16 | 6.29 | 93.55 | 0.03 | 0.30 | 0.06 |
MIDSPAN | 1379 | 0.73 | 7.32 | 91.95 | 0.04 | 0.0002 | |
Ten Towns | 1477 | 0.14 | 6.77 | 93.09 | 0.04 | 0.70 | |
BRHS | 3870 | 0.10 | 6.64 | 93.26 | 0.03 | 0.79 | |
EPIC | 6396 | 0.16 | 6.93 | 92.92 | 0.04 | 0.59 |
BRHS, British Regional Heart Study; BWHHS, British Women's Heart and Health Study; EPIC, European Prospective Investigation into Cancer; MAF, minor allele frequency; SNP; single nucleotide polymorphism.