Table 2.

Summary of effect of FRAX and other predictors of fracture risk in long term care patients

Risk factor	N studies and participants	Association with fractures	Confidence in effect
Predictors in FRAX
Prior fractures	Pooled: 6 studies; 56,781 participants	Moderate increase in risk	Moderate
		RR = 1.71, 95%CI = 1.30-2.24	⊕ ⊕ ⊕O
Female gender	Pooled: 3 studies; 44,433 participants	Small increase in risk	Moderate
		RR = 1.40, 95%CI = 1.00-1.95	⊕ ⊕ ⊕O
Lower BMI*	Pooled: 2 studies; 1,729 participants	Little to no increase in risk HR = 0.94, 95%CI = 0.90-0.98	low
	Not pooled: 1 study; 128 participants		⊕ ⊕ OO
Older age	Not pooled: 5 studies; 44,745 participants	Small increase in risk	low
			⊕ ⊕ OO
Low BMD	Not pooled: 2 studies; 1,708 participants	Moderate to large increase in risk	low
			⊕ ⊕ OO
Glucocorticoid use	Not pooled: 1 study; 1,550 participants	Moderate to large increase in risk	low
			⊕ ⊕ OO
Rheumatoid arthritis	Not pooled: 1 study; 30,665 participants	Little to no increase in risk	low
			⊕ ⊕ OO
Predictors not in FRAX
Psychotropic medication use	Pooled: 3 studies; 45,962 participants	Uncertain	Very low
	Not pooled: 2 studies; 94,859 participants		⊕OOO
Cognitive impairment	Pooled: 2 studies; 14,773 participants	Small increase in risk	Moderate
	Not pooled: 1 study; 1,894 participants	RR = 1.53, 95%CI = 1.09-2.14	⊕ ⊕ ⊕O
Mobility	Not pooled: 3 studies; 30,132 participants	Uncertain	Very low
			⊕OOO
Falls	Pooled: 4 studies; 44,560 participants	Small to moderate increase in risk	Moderate
		RR = 1.28, 95%CI = 1.04-1.58	⊕ ⊕ ⊕O

*Since both studies included in the meta analysis of BMI reported Hazard Ratios, we did not convert them into relative risks and report pooled results as hazard ratios.