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. 2014 Nov 30;16(6):497. doi: 10.1186/s13075-014-0497-x

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© Moret et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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CD4 T cells derived from synovial fluid of rheumatoid arthritis patients are hyporesponsive upon (TSLP-primed) myeloid dendritic cell stimulation in contrast to peripheral blood-derived CD4 T cells. Thymic stromal lymphopoietin (TSLP)-primed myeloid dendritic cells (mDCs) from peripheral blood (PB) as well as both mDCs and TSLP-primed mDCs from synovial fluid (SF) of rheumatoid arthritis (RA) patients strongly activate PB-derived CD4 T cells, whereas SF-derived CD4 T cells are hyporesponsive upon (TSLP-primed) mDC activation. (A) mDC:T cell ratio 1:5, paired analysis of CD4 T cells and mDCs of a representative donor are shown. (B) mDC:T cell ratio 1:10 derived from PB of five RA patients. (C) mDC:T cell ratio 1:10 derived from SF of five RA patients. *P < 0.05 (statistically significant difference). CPM, counts per minute.