FIG. 2.

Morphometric analysis of lymphatic vessels in the subpleural and interstitial compartments. Schematic representation of subpleural and interstitial lymphatics (A). Lung tissue sections showing immunoreactivity with anti-LYVE-1 antibodies, with subpleural and interstitial lymphatic vessels highlighted in (B). (Scale bar: 100 μm). Significant changes in subpleural lymphatic density (C), perimeter (D), and area (E) were observed at the indicated time points following radiation exposure. Changes in interstitial lymphatic density (F), perimeter (G), and area (H) were observed as early as one week post-radiation (n=3 mice per group per time point); *p<0.05; **p<0.01; ***p<0.001, compared to time-matched controls by Student t test. A color version of this figure is available in the online article at www.liebertpub.com/lrb.