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. 2014 Dec 16;7:85. doi: 10.3389/fnmol.2014.00085

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Copyright © 2014 Most, Workman and Harris.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Model for cocaine-induced microRNA-mRNA interactions. Cocaine causes the down-regulation of let-7d, resulting in induction of its target genes, BDNF and cAMP-responsive element-binding protein (CREB). In contrast, miR-181a is up-regulated by cocaine, causing down-regulation of its targets, GRM5 (glutamate metabotropic receptor 5) and AMPA receptor subunit 2 (GluA2). These data support the involvement of let-7d and miR-181a in regulating the differential expression of various genes in response to cocaine, which may impact molecular adaptations leading to addiction. Figure and legend were modified from the original in Jonkman and Kenny (2013).