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. 2014 Dec 16;5:483. doi: 10.3389/fphys.2014.00483

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Copyright © 2014 Cabo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Longitudinal conduction velocity (CV) of double premature impulses with different coupling intervals (S2S3), after a single premature with a coupling interval S1S2 = 200 ms, in a uniform infarcted myocardium preparation with average cell-to-cell coupling Gj = 0.41 μS. (A) Average longitudinal CV in the preparation for different coupling intervals. (B) Local longitudinal CV as the impulse propagates away from the stimulation site (x = 0 mm). (C) Comparison of longitudinal CV restitution curves for single (S2) and double (S3) premature impulses. The diastolic interval (DI) is defined as (S1S2—Refractory period of S1) for S2 and (S2S3—Refractory period of S2) for S3 impulses. Size of the preparation: 10 × 2.5 mm.