Figure 1. Expression of HMGA2 in normal skin, primary melanoma, and melanoma metastases.
(a) Overexpression of HMGA2 probe 208025_s_at was considered above the median (6.29). Orange–gray bar represents primary melanomas that metastasized later (orange). BRAF mutations are shown in yellow and NRAS mutants are showed in blue bars. (b) Pearson correlation between microarray and quantitative PCR HMGA2 expression data (0.84, P<0.0001). (c) Correlation between HMGA2 expression data from microarray and nuclear immunohistochemistry (IHC) intensity staining against HMGA2 (neg, negative staining; pos+, moderate intensity; pos+ +, strong intensity).