Table 1.
Clinicopathological characteristics of study
| Characteristics1 | Discovery set (n =74) | Replication set (n =330) | P-value |
|---|---|---|---|
| Normal tissue (n) | 16 | — | |
| Primary melanoma (not metastatic) (n) | 46 | 330 | |
| Melanoma metastases (n) | 12 | — | |
| Mean age, years (range)2 | 59.4 (20–92) | 54.5 (48–87) | 0.0072 |
| Median Breslow thickness, mm (range) | 3 (0.6–19) | 2.45 (0.25–16.3) | 0.5898 |
| Sex, no. (%) | 0.0916 | ||
| Male | 33 (72%) | 183 (56%) | |
| Female | 13 (28%) | 147 (44%) | |
| Site, no. (%) | 0.2810 | ||
| Head and neck | 10 (22%) | 35 (14%) | |
| Trunk | 12 (26%) | 81 (32%) | |
| Legs | 19 (41%) | 79 (32%) | |
| Arms | 10 (22%) | 48 (19.2%) | |
| Others3 | 0 | 7 (3%) | |
| Not available | 0 | 80 | |
| Melanoma type, no. (%) | 0.5897 | ||
| Superficial spreading melanoma | 28 (61%) | 88 (64%) | |
| Nodular melanoma | 8 (17%) | 26 (19%) | |
| Acrolentiginous melanoma | 3 (7%) | 7 (5%) | |
| Lentigo maligna melanoma | 1 (2%) | 2 (2%) | |
| Desmoplastic melanoma | 1 (2%) | 1 (1%) | |
| Nevoid melanoma | 0 | 1 (1%) | |
| MIS | 2 (4%) | 0 | |
| Unclassified | 0 | 0 | |
| Others4 | 3 (7%) | 12 (9%) | |
| Not available | 0 | 193 | |
| AJCC stage at diagnosis | 0.2390 | ||
| 0 | 2 (4%) | 0 | |
| I | 10 (22%) | 191 (69%) | |
| II | 16 (36%) | 11 (4%) | |
| III | 18 (40%) | 60 (22%) | |
| IV | 0 | 14 (5%) | |
| Not available | 0 | 54 | |
| Ulceration, no. (%) | 0.2516 | ||
| Absent | 28 (61%) | 83 (61%) | |
| Present | 18 (39%) | 54 (39%) | |
| Not available | 0 | 193 | |
| Mitotic rate, no. per mm2 | — | ||
| 0 | 13 (28%) | — | |
| 1–6 | 19 (41%) | — | |
| >6 | 13 (31%) | — | |
| Not available | 0 | 330 | |
| Median follow-up, days | 875 | 1,602 | <0.0001 |
Abbreviation: AJCC, American Joint Committee on Cancer.
1
The characteristics are presented for primary melanomas only.
2
Age of the patients calculated at the first biopsy.
3
Oral, male genital, and female vaginal location.
4
Polypoid, mucosal melanoma, spindle-cell melanoma, Spitz-type melanoma, and amelanotic melanoma.