Figure 1.

Pathological changes and activation of cellular immunity in CVID is partially alleviated after immunoglobulin replacement therapy. IgG replacement therapy restores humoral immunity and provides better control of microbes and pathogens, reducing the infection burden on the immune system. This together with triggering of the FcR-mediated inhibitory effects on antigen presenting cells leads to reduced activation of CD8 T cells, iNKT cells, and DCs (A) and improvement in CD4 T cell counts and DC count (B).