By modifying the geometry and matrix elasticity of the underlying patterns, cells were able to choose lineage commitment based on the physical cues presented. (A)-(D) Shown in these graphs are the effect of shape, size, and matrix elasticity on MSC lineage commitment (E)-(F) Shown on these patterns are adipogenesis and osteogenesis on rectangles, squares, and circles (Scale bars 50 μm). Error bars are standard error from at minimum 2 separate experiments with over 75 cells per condition.