Fig. 5.
The inverted-U component spatially corresponds to the structural pattern of abnormalities in adolescent-onset schizophrenia and correlates with intelligence scale in healthy subjects. (A) The spatial network corresponding to the inverted-U component IC4 (orange) closely matches the gray matter showing altered trajectory in adolescent-onset schizophrenia compared with healthy adolescents (green; thresholded for better visualization at P < 0.05; n = 24; voxel-by-voxel spatial cross-correlation: r = 0.48; P < 10−3). (B) The inverted-U component load for each of the healthy participants plotted against intellectual ability [e.g., block design score (fluid intelligence) from the Wechsler Abbreviated Scale of Intelligence; n = 439; linear fit is in turquoise; r = 0.40; P = 1.8 × 10−18] (SI Materials and Methods and Fig. S5 shows the plot for crystallized intelligence). Results presented here have not been age-corrected, as the relationship between block design scores and age was highly nonlinear. As for episodic memory scores, lifespan trajectory of fluid intelligence matched that of the inverted-U component (Fig. S6), explaining the linear relationship between the two presented in B. a.u., arbitrary unit.