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Relative plasma concentrations assessed by LCMS up to 8 h after administration of 15 at 10 mg/kg p.o. (olive oil) vs. 1 mg/kg i.v. (DMSO) in Wistar rats. The absolute oral bioavailability (F) of 15 was determined to be 33% ± 2.9% (n = 4; error in SD; pharmacokinetic data in SI Appendix, Table S2).
