Table 4.

Significant MF GO terms for the CpGs identified by the Gold-std method in the lung adenocarcinoma case study. The reported P-values are adjusted via the Benjamini–Hochberg FDR control.²⁴

MOLECULAR FUNCTION
GO ID	TERM	ANNOTATED	SIGNIFICANT	EXPECTED	elim.Fisher	elim.KS
GO:0004930	G-protein coupled receptor activity	741	566	440.86	2.51e-10	1.67e-22
GO:0004984	Olfactory receptor activity	67	62	39.86	7.72e-07	2.26e-15
GO:0005509	Calcium ion binding	977	654	581.27	0.000243	1.29e-13
GO:0043565	Sequence-specific DNA binding	1129	735	671.71	0.00888	5.34e-12
GO:0005201	Extracellular matrix structural constitu.	123	95	73.18	0.00634	1.81e-08
GO:0005234	Extracellular-glutamate-gated ion channe.	29	26	17.25	0.0283	6.5e-07
GO:0005125	Cytokine activity	332	234	197.53	0.00604	1.33e-05
GO:0005230	Extracellular ligand-gated ion channel a.	122	99	72.58	0.0147	3.79e-05
GO:0004890	GABA-A receptor activity	33	29	19.63	0.0283	6e-05
GO:0015269	Calcium-activated potassium channel acti.	27	25	16.06	0.0192	0.000132
GO:0004888	Transmembrane signaling receptor activit.	1333	979	793.08	0.0363	0.000591
GO:0005540	Hyaluronic acid binding	32	29	19.04	0.0179	0.00185
GO:0015293	Symporter activity	213	152	126.73	0.0216	0.00232
GO:0020037	Heme binding	201	144	119.59	0.0216	0.00558
GO:0005506	Iron ion binding	238	169	141.6	0.0192	0.00558
GO:0016918	Retinal binding	28	25	16.66	0.0363	0.0104
GO:0005242	Inward rectifier potassium channel activ.	37	32	22.01	0.0283	0.0126
GO:0015279	Store-operated calcium channel activity	16	16	9.52	0.0229	0.0212
GO:0008227	G-protein coupled amine receptor activit.	67	58	39.86	0.0216	0.0315