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. 2014 Sep 15;70(1):136–152. doi: 10.1093/jac/dku349

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© The Author 2014. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Susceptibility of reassortant viruses to NN-DNJ compared with wild-type viruses. Infectious virus titres from single-cycle high-moi assays performed on MDCK cells infected with (a) high-growth vaccine reassortants X-181 and X-171b and wild-type viruses Brisbane/10 and Lviv or (b) H3N1 reassortant and wild-type viruses Brisbane/10 and Lviv and then treated with NN-DNJ. (c) Plaque reduction assays were performed on MDCK cells infected with the H3N1 reassortant and wild-type viruses Brisbane/10 and Lviv and then treated with NN-DNJ. Plaques were fixed and immunostained for NP. In the graphs on the left, means and standard deviations of infectious virus titre of three (a) and two (b and c) independent experiments are plotted against increasing drug concentration. On the right are summary tables of mean IC₅₀ and IC₉₀ values from independent experiments described in (a), (b) and (c), respectively; ± represents the standard deviations (a) or ranges (b and c) from the mean.