Table 1.
Popularity indices (GPI and SPI) of anesthetics
| Name | Introductiona | Number of articles (2009–2013) | GPI (%)b (2009–2013) | SPI (%)c
|
||||
|---|---|---|---|---|---|---|---|---|
| 1989–1993 | 1994–1998 | 1999–2003 | 2004–2008 | 2009–2013 | ||||
| Inhaled anesthetics | ||||||||
| Isoflurane | 1971 | 2,048 | 4.5 | 28.7 | 35.2 | 31.3 | 30.6 | 28.4 |
| Nitrous oxide | 1844 | 1,836 | 4.0 | 26.2 | 23.5 | 20.9 | 15.3 | 11.8 |
| Sevoflurane | 1987 | 1,666 | 3.7 | 3.2 | 14.8 | 27.0 | 30.8 | 32.6 |
| Halothane | 1956 | 406 | 0.9 | 28.8 | 23.6 | 15.9 | 8.8 | 3.6 |
| Desflurane | 1990 | 402 | 0.9 | 3.6 | 9.2 | 6.7 | 9.3 | 7.8 |
| Enflurane | 1968 | 53 | 0.1 | 10.3 | 6.4 | 2.4 | 1.2 | 0.5 |
| Intravenous anesthetics | ||||||||
| Propofol | 1977 | 3,957 | 8.7 | 19.0 | 24.5 | 34.7 | 36.9 | 34.9 |
| Thiopental | 1934 | 399 | 0.9 | 9.6 | 8.9 | 5.7 | 4.2 | 2.5 |
| Etomidate | 1973 | 386 | 0.8 | 2.2 | 2.1 | 2.0 | 2.3 | 2.0 |
| Methohexital | 1960 | 37 | 0.1 | 2.2 | 1.8 | 1.4 | 0.6 | 0.4 |
| Local anesthetics | ||||||||
| Lidocaine | 1947 | 3,667 | 8.1 | 22.8 | 25.3 | 22.4 | 19.8 | 17.5 |
| Bupivacaine | 1963 | 2,230 | 4.9 | 11.3 | 18.1 | 18.2 | 16.6 | 14.4 |
| Ropivacaine | 1996d | 936 | 2.1 | 1.2 | 1.4 | 7.1 | 6.9 | 5.9 |
| Levobupivacaine | 1995 | 379 | 0.8 | – | – | 1.3 | 3.3 | 3.4 |
| Procaine | 1905 | 326 | 0.7 | 3.2 | 1.5 | 1.2 | 1.1 | 0.8 |
| Prilocaine | 1960 | 302 | 0.7 | 3.8 | 4.0 | 3.3 | 2.2 | 2.2 |
| Tetracaine | 1932 | 245 | 0.5 | 2.5 | 3.0 | 2.1 | 1.4 | 1.1 |
| Mepivacaine | 1957 | 211 | 0.5 | 2.2 | 2.4 | 2.4 | 2.0 | 1.4 |
| Benzocaine | 1902 | 170 | 0.4 | 0.4 | 0.6 | 0.9 | 0.5 | 0.5 |
Notes: Only anesthetics with 2009–2013 GPI ≥0.1 are included. Xenon and chloroprocaine did not reach this threshold.
As indicated in Miller’s Anesthesia or Cousin’s and Bridenbaugh’s Neural Blockade.
GPI share of all articles on anesthetics (Anesthetics [MeSH term]) published in 2009–2013.
SPI share of all articles on one of the following types of anesthesia: inhalational anesthesia (Anesthesia, Inhalation [MeSH term]), intravenous anesthesia (Anesthesia, Intravenous [MeSH term]), or local anesthesia (Anesthesia, Local [MeSH term]).
Year of approval by US Food and Drug Administration. Bold font underlines that in contrast to the values in five other columns, values in this column represent different type of calculations: shear of articles on anesthetics, not share of articles on appropriate type of anesthesia.
Abbreviations: GPI, general popularity index; SPI, specific popularity index.