Table 2.
Indices of change and expectations for new anesthetics
| Name | Last of initial 100 articlesa | Number of articles (2009–2013) | Index of change (%)b
|
Index of expectations (%)c
|
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1999–1993 | 1994–1998 | 1999–2003 | 2004–2008 | 2009–2013 | 1989–1993 | 1994–1998 | 1999–2003 | 2004–2008 | 2009–2013 | |||
| General anesthetics | ||||||||||||
| Propofol | 1985 | 3,957 | >100 | 84 | 38 | 20 | 22 | 25.5 | 22.0 | 17.2 | 12.7 | 8.2 |
| Sevoflurane | 1992 | 1,666 | >100 | >100 | 87 | 17 | 15 | 29.8 | 30.0 | 22.2 | 17.2 | 12.1 |
| Desflurane | 1993 | 402 | >100 | >100 | −3 | 18 | 0 | 43.0 | 32.2 | 29.3 | 17.7 | 13.4 |
| Local anesthetics | ||||||||||||
| Ropivacaine | 1996 | 936 | – | >100 | >100 | 26 | 16 | – | 28.4 | 17.7 | 11.9 | 8.4 |
| Levobupivacaine | 2003 | 379 | – | – | >100 | >100 | 33 | – | – | 16.2 | 16.2 | 6.9 |
Notes: Included anesthetics are matched on two criteria: last of the initial 100 articles was published after 1980; and number of articles in 2009–2013 was ≥50.
a
Publication year of the last of the initial 100 articles.
b
Changes in number of publications compared with number of publications on the same topic in the previous 5 years.
c
An index assessing probability of success, ie, the Top Journal Selectivity Index (TJSI, which is the ratio of the number of all types of articles on a particular topic in the top 20 journals relative to the number of articles in all [>5,000] biomedical journals covered by PubMed over 5 years).