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Summary of Enzyme Effects on Oct4, Nanog, and Rex1 Following Hyperosmotic Stress in mESC Monolayer Culture
| Transcription factor | Enzymes regulating initial stress responses; loss of TF expression at 4 h | Enzymes regulating long-term adaptive stress responses at 24 h |
|---|---|---|
| Oct4 | Mek1>Mek2 PI3K | p38MAPK (rescue of expression) Mek2 (putatively) |
| Nanog | Mek>Mek2 JNK | p38MAPK (rescue of expression) PI3K |
| Rex1 | Mek1 | JNK (ongoing suppression) |
TF, transcription factor.
