Table 2.

Gene-environment interactions between JAZF1 rs10486567 (referent CT or TT) and sources of cadmium and lead exposure in African American prostate cancer cases and controls. (Case-only and Case-control)

	Case-Only					Case-Control
	JAZF1 rs10486567					JAZF1 rs10486567
Exposure	CC N(%)	CT or TT N(%)	OR*	95% CI	p	IOR*	95% CI	p
Smoking
Never	45 (34.1)	28 (29.2)	ref			ref
≤21 packyears	45 (34.1)	37 (38.5)	0.77	0.40-1.48	0.44	0.82	0.21-3.12	0.76
>21 packyears	42 (31.8)	31 (32.3)	0.87	0.43-1.73	0.69	1.13	0.31-4.20	0.85
Housing Built
Before 1950†
Low	57 (43.5)	57 (59.4)	ref			ref
High	74 (56.5)	39 (40.6)	1.81	1.04-3.16	0.04	2.33	0.77-7.03	0.13
Occupational Metal
Cadmium
No Cd	106 (80.3)	81 (84.4)	ref			ref
Any Cd	26 (19.7)	15 (15.6)	1.30	0.64-2.64	0.46	0.85	0.18-3.97	0.83
Lead
No Pb	40 (30.3)	34 (35.4)	ref			ref
Low Pb	41 (31.1)	34 (35.4)	0.96	0.50-1.86	0.90	0.73	0.21-2.55	0.62
High Pb	51 (38.6)	28 (29.2)	1.46	0.76-2.81	0.26	1.98	0.54-7.22	0.30

Abbreviations: Interaction odds ratio (IOR), confidence interval (CI), Housing built before 1950, less than or equal median proportion (Low), greater than median proportion (High), Lead, less than or equal to median for those exposed (Low Pb), greater than median for those exposed (High Pb).

^*OR and IOR adjusted for age and BPH.

^†GEE used for models based on Census tracts.