Table 3.

Case-control associations between JAZF1 rs10486567 (referent CT or TT) and risk of prostate cancer stratified by sources of Cd and Pb exposure in African American men

	Control N	Case N	ORa,b,c,d	95% CI	p	ORa,b,c,d	95% CI	p
Smoking
Never-CT or TT	9	28	ref
Never-CC	11	45	1.26a	0.76- 2.12	0.37
≥21 packyears-CT or TT	14	37	1.46a	0.59- 3.59	0.41	ref
≥21 packyears-CC	14	45	1.14a	0.48- 2.72	0.77	1.03a	0.42- 2.50	0.95
>21 packyears- CT or TT	18	31	1.22a	0.52- 2.84	0.65	ref
>21 packyears- CC	16	42	0.69a	0.30- 1.59	0.38	1.48a	0.62- 3.53	0.37
Census Tract Housing Built Before 1950
Low-CT or TT	18	58	ref
Low-CC	19	61	0.84b	0.36- 1.95	0.68
High-CT or TT	23	38	0.46b	0.21- 0.97	0.05	ref
High-CC	22	71	0.94b	0.45- 1.97	0.88	2.03b	0.99- 4.19	0.05
Occupational Metal
Cadmium
No Cd-CT or TT	37	81	ref
No Cd-CC	35	106	1.28c	0.73- 2.24	0.38
Any Cd-CT or TT	4	15	1.66c	0.50- 5.48	0.40	ref
Any Cd-CC	6	26	1.86c	0.47- 1.49	0.22	1.05c	0.24- 4.66	0.95
Lead
None-CT or TT	13	34	ref
None-CC	13	40	1.13d	0.46- 2.79	0.79
Low-CT or TT	13	34	1.05d	0.41- 2.70	0.92	ref
Low-CC	17	41	0.91d	0.37- 2.25	0.83	0.79d	0.32- 1.95	0.62
High-CT or TT	15	28	0.57d	0.23- 1.46	0.24	ref
High-CC	11	51	1.14d	0.45- 2.91	0.78	2.50d	1.01- 6.18	0.05

Abbreviations: odds ratio (OR), confidence interval (CI). Occupational lead low ≥ 3.2 and high > 3.2. Census tract housing built before 1950 low ≥ 48.4% and high > 48.4%. GEE used for all models.

^aOR adjusted for age, BPH, and occupational Cd. Adjusting for Pb in place of Cd did not change result.

^bOR adjusted for age, BPH, and occupational Pb.

^cOR adjusted for age, BPH, and smoking.

^dOR adjusted for age, BPH, and Census tract housing built before 1950.