Fig 2.

Effect of behavioral intervention (adult) or metformin (child) on antipsychotic-associated weight gain in two studies. Weight trajectory (grey lines) over 24 weeks in adults taking antipsychotic medication for schizophrenia who initiated behavioral intervention for weight (n=59) and controls (n=51) who did not receive intervention [158]. Weight trajectory (solid and dotted black dotted lines) over 16 weeks in children taking antipsychotic medication for 38 also prescribed metformin as adjunctive therapy (n=18) compared to controls not receiving metformin (n=20) [156].