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. Author manuscript; available in PMC: 2014 Dec 16.
Published in final edited form as: Int Rev Neurobiol. 2012;104:135–157. doi: 10.1016/B978-0-12-398323-7.00006-9

Figure 10.

Figure 10

Comt brain network. The mutation in Comt, actually the insertion of a B2 SINE element in the 3’ UTR of C57BL/6J (Blue Comt gene in figure center), causes the production of a shorter mRNA in the B-Type parental strain. GeneNetwork tools and the wealth of data compiled for the BXD family were used to determine what transcripts and phenotypes mapped back to the physical location of the mutation in the Comt gene. Downstream gene targets of the mutation in Comt are shown in the inner ring and downstream phenotypes are shown in the outer ring for four brain regions. Higher expression of the trait associated with inheritance of the B- or D-type allele is shown in red or blue, respectively. Biological process is indicated by color.