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The SRSF1 RRM2 is required and sufficient to abolish Tat transactivation. (A) Schematic representation of the SRSF1 deletion clones. (B) Luciferase activity in HEK293 cells transfected with the pLTR-Xm-LR reporter, the Tat expression vector, the control pEGFP and the SRSF1 expression constructs. (C) Relative expression level of the T7-tagged SRSF1 deletion clones.
