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. 2014 Nov 26;42(22):13969–13980. doi: 10.1093/nar/gku1253

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© The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — The two tandem splice sites in each strongly regulated GYNNGY are more similar to each other than those in GYNNGYs under weaker or unregulation. (A) Comparison of absolute splice score (SS) differences among different groups. SR, strongly regulated; OR, other less regulated; UR, unregulated. Splice site scores are measured with four different methods (‘MAXENT’, ‘MDD’, ‘MM’ and ‘WMM’). All comparisons are significant (Wilcoxon rank sum test, all P < 0.001). (B) The consensus sequences of GYNNGY splice sites. For each group, the GYNNGYs are further divided into two: one mainly using the first GY (distal major) and one mainly using the second GY (proximal major).