Table 2. Target-binding peptide motifs (patterns of conserved residues) found after one round of selection.
| Target | Library | Peptide motifs | Number of sub-families | Different peptides with motifs in top 200 | Different peptides with motifs in whole pool | % of population containing a binding motif |
|---|---|---|---|---|---|---|
| SrtA | Library A | LPP | 15 | 143 (72%) | 1531 (41%) | 47% |
| SrtA | Library B | LPP | 14 | 164 (82%) | 1253 (54%) | 81% |
| uPA | Library B | T/SAR | 14 | 165 (82%) | 1943 (42%) | 70% |
| K/RF/YS/TL | 2 | 8 (4%) | 44 (1%) | 2.7% | ||
| FXIIa | 4×4 | RPCP | 1 | 2 (1%) | 23 (0.2%) | 0.4% |
| VXXKCL | 1 | 5 (2%) | 93 (1%) | 1.2% | ||
| PK | 3×3, 4×4 | F/Y\W XXCRV | 11 | 90 (45%) | 758 (43%) | 43% |
| SA | 3×3, 4×4 | HPQ | 2 | 17 (8.5%) | 37 (9%) | 7.4% |