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. Author manuscript; available in PMC: 2014 Dec 16.
Published in final edited form as: Cell Metab. 2008 Sep;8(3):186–200. doi: 10.1016/j.cmet.2008.08.006

Figure 2. Expression Profiles of Genes Placed at the Type 2 Diabetes Loci Identified to Date.

Figure 2

(A) Expression levels across different tissues.

(B) Relative expression levels in skeletal muscle and pancreatic islets from diabetic and nondiabetic subjects. Skeletal muscle expression data were derived from a cohort of metabolically characterized Mexican-American subjects with established DM2, treated with sulfonylureas or lifestyle only (n = 5), and compared with control individuals with normal glucose tolerance (n = 6) (Patti et al., 2003). The data on pancreatic islets were derived from isolated islets purified from five type 2 diabetic subjects and seven normoglycemic controls (Gunton et al., 2005). The mean duration of type 2 diabetes was 5.8 ± 2.1 years, and no subjects were insulin requiring. Mean HbA1c was 7.5 ± 0.5% in the diabetic subjects. RNA was extracted from at least 1000 islet equivalents per subject. RNA was prepared separately for each subject and hybridized to Affymetrix U133A and B microarrays. For each study, cRNA was prepared separately for each subject and hybridized to Affymetrix HuGene FL (muscle) and U133A and B (islet) microarrays. Complete microarray data sets are available on the Diabetes Genome Anatomy Project (DGAP) website (http://www.diabetesgenome.org).