Table 1.
Methotrexate pharmacokinetic profiles for courses 1–6 with model estimates
| MTX course | MTX dose (g/m2) | Infusion time (hr) | Methotrexate Plasma Concentrations (uM) | Cl (mL/min/m2) | AUC (uM hr)* | Cmax (uM)* | |||
|---|---|---|---|---|---|---|---|---|---|
| Time | |||||||||
| Peak | 24 hr | 48 hr | 72 hr | ||||||
| 1 | 12 | 4 | 1627 | 61 | 0.75 | 0.62 | 30.99 | 13637 | 1651 |
| 2 | 5.2 | 2.6 | 578.6 | 2.9 | 0.25 | 0.08 | 52.59 | 3632 | 673.7 |
| 3 | 8 | 6 | 797.6 | 2.1 | 0.46 | 0.14 | 65.23 | 4640 | 814.1 |
| 4 | 8 | 6 | 809.6 | 3.6 | 0.35 | 0.13 | 59.67 | 5024 | 827.4 |
| 5 | 8 | 4 | 809.4 | 1.1 | 0.12 | 0.03 | 62.69 | 4499 | 862.4 |
| 6 | 10 | 4 | 842.4 | 1.7 | 0.15 | 0.04 | 79.43 | 4775 | 869.1 |
*
calculations based on pharmacokinetic model estimations
MTX, methotrexate; CL, clearance; AUC, area under the methotrexate plasma concentration-time curve; Cmax, peak methotrexate plasma concentration.