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. 2014 Dec 16;9(12):e114086. doi: 10.1371/journal.pone.0114086

Figure 3. Rearing counts in unilateral 6-OHDA-lesioned rats.

Figure 3

The effects of the A2A/NR2B receptor antagonist combinations, given without l-Dopa, were compared with those of the drugs alone for the number of rearing counts: Sch-58261 (1 mg/kg) + Merck 22 (1 mg/kg); Sch-58261 (1 mg/kg) + Co-101244 (1 mg/kg); Preladenant (0.1 mg/kg) + Merck 22 (0.3 mg/kg); Preladenant (0.1 mg/kg) + Radiprodil (1 mg/kg); Tozadenant (30 mg/kg) + Radiprodil (3 mg/kg); Istradefylline (0.3 mg/kg) + Co-101244 (1 mg/kg). Administration of the combinations resulted in significantly greater rearing counts than administration of the drugs alone (Table 8; Three-way mixed ANOVA followed by Newman-Keuls post hoc test).