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. 2014 Dec 16;9(12):e114086. doi: 10.1371/journal.pone.0114086

Figure 4. L-Dopa-induced contralateral rotations in unilateral 6-OHDA-lesioned rats.

Figure 4

The effects of the A2A/NR2B receptor antagonist combinations, given with L-Dopa, were compared with those of the antagonists alone for the number of contralateral rotations: Sch-58261 (0.3 mg/kg) + Co-101244 (1 mg/kg); Preladenant (0.03 mg/kg) + Radiprodil (0.3 mg/kg); Preladenant (0.03 mg/kg) + Merck 22 (1 mg/kg); Tozadenant (30 mg/kg) + Radiprodil (3 mg/kg). All combinations showed significant greater contralateral rotations than vehicle for the respective time intervals (Table 9; Three-way ANOVA and planned contrasts [*p<0.05 and **p<0.01 versus vehicle group]).