Table 1. Adenosine A2A antagonists and their affinity for the receptor: in vitro binding.
| A2A antagonists | Pharmaceutical Company | Ki a A2A | Ki A1 | Ki A2B | Ki A3 | References |
| Istradefylline | Kyowa Hakko Kirin Co Ltd | 12 | 841 | >10,000 | 4,470 | [71] |
| Sch-58261 | Schering-Plough | 0.6 | 287 | 5,011 | >10,000 | [71], [72] |
| Merck & Co Inc | 5 | 725 | 1110 | 1200 | ||
| Preladenant | Merck & Co Inc | 1.1 | >1000 | >1,700 | >1,000 | [73] [71] |
| 0.9 | >1000 | >1000 | ||||
| Tozadenant | Biotie Therapies | 4.9 | 1,320 | ND | ND | [71] |
a
Ki is expressed in nM (rat or human).
ND: no data available.