Table 2. NR2B antagonists and their affinity for the receptor: in vitro and functional binding.

NR2B antagonists	Pharmaceutical Company	NR2B	NR2A	NR2C	Assays	References
Merck 22	Merck & Co Inc	Ki = 0.88 nM	ND	ND	In vitro Binding	[49]
Radiprodil	Gedeon Richter	IC50 = 3–10 nM	IC50>10 µM	ND	In vitro Binding	[69]
	UCB
Co-101,244	Parke-Davis	IC50 = 0.026 µM	IC50 = 230 µM	IC50 = 590 µM	TEVC recording	[33], [74]
	Pfizer	IC50 = 0.043 µM	IC50>100 µM	IC50>100 µM
		IC50 = 4 nM			In vitro binding	[75]

ND: no data available.