Table 3. A2A and NR2B receptor antagonist combinations tested either alone or in combination in monotherapy (i.e. without L-Dopa) in 6-OHDA-lesioned rats.
| A2A receptor antagonist drugs | NR2B receptor antagonist drugs |
| Sch-58261 1 mg/kg (ip) | Merck 22 1 mg/kg (ip) |
| Sch-58261 1 mg/kg (ip) | Co-101244 1 mg/kg (ip) |
| Preladenant 0.1 mg/kg (ip) | Merck 22 0.3 mg/kg (ip) |
| Preladenant 0.1 mg/kg (ip) | Radiprodil 1 mg/kg (ip) |
| Tozadenant 30 mg/kg (po) | Radiprodil 3 mg/kg (po) |
| Istradefylline 0.3 mg/kg (ip) | Co-101244 1 mg/kg (ip) |