Table 5. Plasma and brain exposure of Tozadenant and Radiprodil administered alone or in combination.
| Sample | Dosing regimena | Tozadenant (µg/mL) | Radiprodil (µg/mL) |
| Plasma | Tozadenant | 6.05±0.95 | - |
| Radiprodil | - | 4.96±0.85 | |
| Tozadenant + Radiprodil | 5.04±0.14 | 5.59±2.93 | |
| Brainb | Tozadenant | 0.18±0.04 | - |
| Radiprodil | - | 2.63±0.56 | |
| Tozadenant + Radiprodil | 0.11±0.04 | 2.59±2.48 |
Results expressed as mean ± standard deviation of three animals.
a
Both compounds were delivered orally at 30 mg/kg with samples obtained 60 min after dosing.
b
Concentrations expressed per g tissue.