Table 6. Plasma and brain exposure of Sch-58261 and Co-101244 administered alone or in combination.
| Sample | Dosing regimena | Sch-58261 (ng/mLb) | Co-101244 (ng/mL) |
| Plasma | Sch-58261 | 97.2±10.1 | - |
| Co-101244 | - | 54.7 (n = 2) | |
| Sch-58261+Co-101244 | 112±4.16 | 55.4±8.32 | |
| Brainb | Sch-58261 | 246±34.7 | - |
| Co-101244 | - | 443 (n = 2) | |
| Sch-58261+Co-101244 | 264±38.3 | 436±74.0 |
Results expressed as mean ± standard deviation of three animals.
a
Both compounds were delivered ip at 3 mg/kg with samples obtained 90 min after dosing.
b
Concentrations expressed per g tissue.