Table 7. Statistical analysis for the distance traveled following administration of A_2A and NR2B receptor antagonist combinations.

	A2A antagonist	NR2B antagonist	A2A×NR2B interaction	Comment
	Sch-58261	Merck 22	Combination	Synergistic effect
Drugs main effecta	p<0.001	p<0.001	p<0.05	between
Drugs × Time effect a	Not significant	p<0.001	p<0.05	Sch-58261
Combination vs drugs aloneb			Both p<0.001	and
Drugs alone vs vehicleb			Both p<0.01	Merck 22
	Sch-58261	Co-101244	Combination	Synergistic effect
Drugs main effecta	p<0.001	p<0.001	p<0.001	between
Drugs × Time effect a	p<0.001	p<0.001	Not significant	Sch-58261
Combination vs drugs aloneb			Both p<0.001	and
Drugs alone vs vehicleb			Both p<0.01	Co-101244
	Preladenant	Merck 22	Combination	Additive effect
Drugs main effecta	p<0.001	p<0.001	Not significant	between
Drugs × Time effect a	Not significant	p<0.001	Not significant	Preladenant
Combination vs drugs aloneb			Both p<0.01	and
Drugs alone vs vehicleb			Preladenant: p<0.001	Merck 22
			Merck 22: p<0.05
	Preladenant	Radiprodil	Combination	Synergistic effect
Drugs main effecta	p<0.001	p<0.001	p<0.05	between
Drugs × Time effect a	Not significant	p<0.001	Not significant	Preladenant
Combination vs drugs aloneb			Both p<0.001	and
Drugs alone vs vehicleb			Both p<0.05	Radiprodil
	Tozadenant	Radiprodil	Combination	Additive effect
Drugs main effecta	p<0.05	p<0.01	Not significant	between
Drugs × Time effect a	p<0.001	p<0.001	Not significant	Tozadenant
Combination vs drugs aloneb			Both p<0.01	and
Drugs alone vs vehicleb			Not significant	Radiprodil
	Istradefylline	Co-101244	Combination	Additive effect
Drugs main effecta	p<0.001	p<0.05	Not significant	between
Drugs × Time effect a	Not significant	p<0.001	Not significant	Istradefylline
Combination vs drugs aloneb			Both p<0.05	and
Drugs alone vs vehicleb			Not significant	Co-101244

^aPrimary statistical analyses conducted via Three-way mixed ANOVA;

^bPost hoc analyses conducted via Newman-Keuls test.