. 2014 Dec 16;9(12):e114086. doi: 10.1371/journal.pone.0114086

Table 8. Statistical analysis for the rearing counts following administration of A_2A and NR2B receptor antagonist combinations.

	A_2A antagonist	NR2B antagonist	A_2A×NR2B interaction	Comments
	Sch-58261	Merck 22	Combination	Additive effect
Drugs main effect^a	p<0.001	p<0.001	Not significant (p = 0.07)	between
Drugs × Time effect ^a	p<0.001	p<0.001	Not significant	Sch-58261 and
Combination vs drugs alone^b			Both p<0.001	Merck 22
Drugs alone vs vehicle^b			Sch-58261 p<0.05
			Merck 22, not significant
	Sch-58261	Co-101244	Combination	Synergistic effect
Drugs main effect^a	p<0.001	p<0.001	p<0.001	between
Drugs × Time effect ^a	p<0.001	p<0.001	p<0.05	Sch-58261
Combination vs drugs alone^b			Both p<0.001	and Co-101244
Drugs alone vs vehicle^b			Both p<0.05
	Preladenant	Merck 22	Combination	Synergistic effect
Drugs main effect^a	p<0.001	p<0.01	Not significant	between
Drugs × Time effect ^a	p<0.001	Not significant	p<0.01	Preladenant
Combination vs drugs alone^b			Both p<0.01	and Merck 22
Drugs alone vs vehicle^b			Preladenant p<0.001	when
			Merck 22, not significant	time included
	Preladenant	Radiprodil	Combination	Additive effect
Drugs main effect^a	p<0.001	p<0.001	Not significant	between
Drugs × Time effect ^a	Not significant	p<0.01	Not significant	Preladenant
Combination vs drugs alone^b			Both p<0.01	and Radiprodil
Drugs alone vs vehicle^b			Preladenant p<0.001
			Radiprodil, not significant
	Tozadenant	Radiprodil	Combination	Additive effect
Drugs main effect^a	p<0.01	p<0.01	Not significant (p = 0.06)	between
Drugs × Time effect ^a	p<0.001	p<0.001	Not significant	Tozadenant
Combination vs drugs alone^b			Both p<0.01	and
Drugs alone vs vehicle^b			Not significant	Radiprodil
	Istradefylline	Co-101244	Combination	Additive effect
Drugs main effect^a	p<0.001	Not significant	Not significant	between
Drugs × Time effect ^a	p<0.01	p<0.01	Not significant	Istradefylline
Combination vs drugs alone^b			Co-101244, p<0.01	and
Drugs alone vs vehicle^b			Istradefylline, p<0.01	Co-101244
			Co-101244, not significant

Primary statistical analyses conducted via Three-way mixed ANOVA;

Post hoc analyses conducted via Newman-Keuls test.

Table 8. Statistical analysis for the rearing counts following administration of A2A and NR2B receptor antagonist combinations.

Table 8. Statistical analysis for the rearing counts following administration of A_2A and NR2B receptor antagonist combinations.