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. 2014 Dec 16;9(12):e114086. doi: 10.1371/journal.pone.0114086

Table 9. Statistical analysis for the contralateral rotations following administration of A_2A and NR2B receptor antagonist combinations as add-on treatment to l-Dopa.

	A_2A antagonist	NR2B antagonist	A_2A×NR2B interaction	Comments
	Sch-58261	Co-101244	Combination	Additive effect
Drugs main effect^a	p<0.05	Not significant	Not significant	between
Drugs × Time effect^a	p<0.001	p<0.001	Not significant	Sch-58261
Combination vs vehicle^b			p<0.05 for 30′	And
Drugs alone vs vehicle^b			Sch-58261, p<0.05 for 10′	Co-101244
	Preladenant	Merck 22	Combination	Additive effect
Drugs main effect^a	p<0.05	Not significant	Not significant	between
Drugs × Time effect^a	p<0.001	p<0.01	Not significant	Preladenant
Combination vs vehicle^b			p<0.05 for 40′	and
Drugs alone vs vehicle^b			Not significant	Merck 22
	Preladenant	Radiprodil	Combination	Additive effect
Drugs main effect^a	p<0.01	Not significant	Not significant	between
Drugs × Time effect^a	p<0.001	p<0.01	Not significant	Preladenant
Combination vs vehicle^b			p<0.05 for 40′	and
Drugs alone vs vehicle^b			Not significant	Radiprodil
	Tozadenant	Radiprodil	Combination	Additive effect
Drugs main effect^a	p<0.001	p<0.01	Not significant	between
Drugs × Time effect^a	p<0.001	p<0.001	Not significant	Tozadenant
Combination vs vehicle^b			p<0.05 for 120′	and
Drugs alone vs vehicle^b			Tozadenant p<0.05 for 80′	Radiprodil
			Radiprodil p<0.05 for 20′

^a

Primary statistical analyses conducted via Three-way mixed ANOVA;

^b

A priori Planned Contrasts done on each.

10-min time interval of rotations recording.