Table 3.
Significantly associated clinical and laboratory variables at first presentation of dengue-infected ICU (cases) compared to non-ICU (controls) patients
| Variables | Den-infected non-ICU controls (n = 108) | %/(IQR) | Den-infected ICU cases (n = 27) | %/(IQR) | COR | P-value | 95% CI | ACOR* | P-value | 95% CI |
|---|---|---|---|---|---|---|---|---|---|---|
| Hypoproteinemia | ||||||||||
| Yes | 23 | 21 | 10 | 37 | 2.28 | 0.085 | 0.89–5.85 | 4.65 | 0.037 | 1.09–19.74 |
| Hypotension | ||||||||||
| Yes | 4 | 3.7 | 7 | 26 | 8.62 | 0.002 | 2.21–33.63 | 7.63 | 0.005 | 1.83–31.79 |
| Severe organ involvement | ||||||||||
| Yes | 1 | 0.9 | 10 | 37 | 40 | <0.001 | 5.12–312.5 | 33.04 | 0.003 | 3.30–331.3 |
| Hematocrit change ≥20% concurrent with platelet <50 K | ||||||||||
| Yes | 7 | 6.5 | 11 | 41 | 9.4 | <0.001 | 2.95–29.83 | 8.66 | 0.001 | 2.46–30.53 |
| Systolic blood pressure | 105 | (100–114) | 110 | (91.5–118.5) | 0.98 | 0.216 | 0.96–1.01 | 0.97 | 0.046 | 0.94–0.99 |
| Pulse rate | 90 | (80–96) | 95.5 | (88.5–102) | 1.03 | 0.049 | 1.00–1.07 | 1.05 | 0.012 | 1.01–1.09 |
| Proportion neutrophils | 60.3 | (46.2–70.4) | 76.8 | (70.7–81.5) | 1.11 | <0.001 | 1.05–1.18 | 1.11 | 0.001 | 1.04–1.17 |
| Proportion lymphocytes | 30.3 | (22–39) | 16.5 | (9.8–19.9) | 0.90 | <0.001 | 0.85–0.95 | 0.90 | 0.001 | 0.85–0.96 |
| Proportion monocytes | 12.5 | (8.9–17.3) | 7.9 | (5.1–9.9) | 0.84 | 0.002 | 0.76–0.94 | 0.86 | 0.004 | 0.77–0.95 |
| Platelet | 68 | (44–84) | 42.5 | (20.3–74.8) | 0.98 | 0.01 | 0.96–0.99 | 0.98 | 0.017 | 0.96–0.99 |
| Serum urea | 3.5 | (2.6–4.6) | 5.1 | (3.7–6.8) | 1.33 | 0.002 | 1.11–1.58 | 1.26 | 0.030 | 1.02–1.56 |
| Serum creatinine | 77 | (65–88.3) | 102 | (82.3–130) | 1.03 | 0.001 | 1.01–1.04 | 1.02 | 0.006 | 1.01–1.04 |
| Serum AST | 114 | (70–195) | 156.5 | (96.5–516) | 1.01 | 0.017 | 1.00–1.04 | 1.01 | 0.019 | 1.00–1.04 |
| Serum ALT | 74 | (38–121) | 92 | (55.8–293.3) | 1.01 | 0.012 | 1.001–1.06 | 1.01 | 0.017 | 1.001–1.06 |
| Serum protein | 67 | (63–72) | 66 | (60.5–68.5) | 0.89 | 0.016 | 0.79–0.98 | 0.88 | 0.022 | 0.79–0.98 |
| Serum albumin | 37 | (35–40) | 37 | (31–39) | 0.8 | 0.004 | 0.69–0.93 | 0.81 | 0.006 | 0.70–0.94 |
DPF- Days Post Fever; DPP- Days Post Presentation; LOS- Length of Stay; COR- Conditional Odds Ratio; IQR- Interquartile range.
*Adjusted Conditional Odds Ratio (ACOR) was obtained from a multivariate conditional logistic regression with test variables being adjusted by age and diabetes mellitus. Data in bold are risk factors involved in the most optimal predictive model of ICU requirement at first presentation.