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. 2014 Sep 5;15(1):106. doi: 10.1186/s12931-014-0106-1

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© Hou et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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NE-induced PlGF promoter activity is mediated by Egr-1. (A, E, and F) The placenta growth factor (PlGF) promoter activity was evaluated by luciferase activity. (B) Hypoxia inducible factor (HIF)-1alpha and metal-regulatory transcription factor (MTF)-1, (C) Egr-1, and β-actin were analyzed by Western blot analysis. (D) The association of Egr-1 and PlGF promoter fragment was evaluated by chromatin immuno-precipitation assay. Data are presented as mean ± SEM. ^* p < 0.05 vs. vehicle-treated group.